
Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!

as Momoko Akatsutsumi / Hyper Blossom (voice)

as Miyako Goutokuji / Rolling Bubbles (voice)

as Kaoru Matsubara / Powered Buttercup (voice)

as Ken Kitazawa

as Professor Utonium Kitazawa

as Mojo Jojo

as Mayor

as Peach

as Princess Morbucks

as Brick

as Him

as Boomer

as Miss Sara Bellum

as Butch

as Kuriko Akatsutsumi

as Math Teacher

as Takaaki "Taka-chan"

as Tokio Matsubara

as Little Arturo

as Grubber

as Snake

as Miko Shirogane

as Silk Hat

as Poncho

as Miss Keane

as Sedusa

as Doctor

as Fuzzy Lumpkins

as Lady

as Kiyoko Gotokuji