Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!
as Momoko Akatsutsumi / Hyper Blossom (voice)
as Miyako Goutokuji / Rolling Bubbles (voice)
as Kaoru Matsubara / Powered Buttercup (voice)
as Ken Kitazawa
as Professor Utonium Kitazawa
as Mojo Jojo
as Mayor
as Peach
as Princess Morbucks
as Brick
as Him
as Boomer
as Miss Sara Bellum
as Butch
as Kuriko Akatsutsumi
as Math Teacher
as Takaaki "Taka-chan"
as Tokio Matsubara
as Little Arturo
as Grubber
as Snake
as Miko Shirogane
as Silk Hat
as Poncho
as Miss Keane
as Sedusa
as Doctor
as Fuzzy Lumpkins
as Lady
as Kiyoko Gotokuji
